Tandem and domino reactions constitute economic methodologies to prepare complex
molecules starting from simple materials. Especially, combining these powerful procedures
to asymmetric catalysis allows direct access to many elaborated chiral products, including
important key intermediates in total syntheses of important biologically active compounds.
A range of various types of chiral organocatalysts have already been successfully
applied to such syntheses. This review presents major developments in the total synthesis of
bioactive products based on the use of enantioselective organocatalytic domino/tandem reactions
as key steps. It is divided into three parts, dealing successively with syntheses based on
organocatalytic asymmetric Michael-initiated domino reactions as key steps; aldol-initiated
domino/tandem reactions and other domino reactions.
Keywords: Total synthesis, bioactive products, enantioselective domino/tandem reactions, organocatalysis, asymmetric catalysis, chirality.
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