Red cell distribution width (RDW) serves as an independent predictor towards the prognosis of coronary artery
disease (CAD) in patients undergoing percutaneous coronary intervention (PCI). A systematic search of databases such as
PubMed, Embase, Web of Science, and Cochrane library was performed on October 10th, 2019 to elaborate the
relationship between RDW and in hospital and long term follow up all-cause and cardiovascular mortality, major adverse
cardiac events (MACE) and development of contrast-induced nephropathy (CIN) in patients with CAD undergoing PCI.
Twenty-one studies qualified this strict selection criteria (number of patients = 56,425): one study was prospective, and
the rest were retrospective cohorts. Our analysis showed that patients undergoing PCI with high RDW had a significantly
higher risk of in-hospital all-cause mortality (OR 2.41), long-term all-cause mortality (OR 2.44), cardiac mortality (OR
2.65), MACE (OR: 2.16) and odds of developing CIN (OR: 1.42) when compared to the patients with low RDW.
Therefore, incorporating RDW in the predictive models for the development of CIN, MACE, and mortality can help in
triage to improve the outcomes in coronary artery disease patients who undergo PCI.