The Influence of Surface Charge on the Antiviral Effect of Curcumin Loaded in Nanocarrier System

(E-pub Ahead of Print)

Author(s): Najwa Nabila, Siti Riqqah Hassan, Gladys Pinkan Larasati, Benediktus Yohan, R. Tedjo Sasmono, Annis Catur Adi, Ferry Iskandar, Heni Rachmawati*

Journal Name: Pharmaceutical Nanotechnology


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Abstract:

Background : Curcumin is a well-documented bioactive compound present in Curcuma sp., a tropical medicinal plant. This substance exhibits broad spectrum biological activities including antivirus. Despite, the lack of pharmaceutical properties of curcumin limits its clinical use.

Objective : This study aims to produce curcumin nanoemulsion with different surface charge (curcumin (+) nanoemulsion and curcumin (-) nanoemulsion) and to evaluate its physical characteristics, in vitro cell cytotoxicity and antiviral activity against dengue virus (DENV) 1 and 2.

Methods : Two forms of nanoemulsion were prepared which were differed from their surface charge through spontaneous procedure resulting similar characteristics except the zeta potential value. Cytotoxicity was determined using RT-PCR method in A549 cell line and anti-DENV properties were determined by calculation of inhibitory concentration 50 (IC50) value.

Results : The positively charge of curcumin-loaded nanoemulsion showed better effect in reducing the viral replication represented by lower IC50 value. In addition, DENV-1 was more sensitive and responsive to curcumin as compared to DENV-2.

Conclusion : Positive surface charge of curcumin-loaded nanoemulsion improves the antiviral effect of the curcumin suggesting a promising approach for alternative treatment for dengue virus infection.

Keywords: curcumin, dengue virus, nanoemulsion, surface charge, antiviral activity

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Article Details

(E-pub Ahead of Print)
DOI: 10.2174/2211738509666210204121258
Price: $95

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