Background: Novel drug delivery systems have always been of immense interest for
research. The majority of the drugs suffer from solubility related constraints. Lipid-based drug
delivery systems provide a promising approach to address this issue. Amongst various approaches,
liquid crystalline systems offer distinct advantages over other available options. It maintains the
phase stability between solid and liquid phases.
Objective: Lyotropic Liquid Crystals (LLCs) have highly ordered internal structure forming
capabilities, thereby assisting the controlled release of a therapeutic agent of varying sizes and
Methods: The present article covers the structural features of dispersed mesophases (cubosomes and
hexosomes), components used to prepare various mesophases, methods of preparation,
characterization techniques, and potential applications.
Results: LLCs offers a distinct choice for delivering hydrophobic as well as hydrophilic drug. They
are also suitable for the delivery of macromolecules such as peptides and proteins through various
routes of administration. Lyotropic liquid crystals are extremely versatile drug delivery systems that
can be used for delivering drugs across topical, oral, buccal, pulmonary, and intravenous routes.
Their use in the delivery of drugs that are tough to deliver, hormones, peptides, biomolecules, and
vaccines is particularly important.
Conclusion: This review discusses the composition, methods of preparation, and characterization of
LLCs. The LLCs offer promising delivery choices for drugs with lower solubility and higher