Hydroxychloroquine (HCQ) and its Synthetic Precursors: A Review

(E-pub Ahead of Print)

Author(s): Rafi Shaik*, H. Surya Prakash Rao

Journal Name: Mini-Reviews in Organic Chemistry

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Hydroxychloroquine (HCQ) is an extremely important drug used for treatment of various ailments. WHO listed it as one of the essential drugs. Utility of hydroxychloroquine (HCQ) as prophylaxis of COVID19, although debated, is well known. We have reviewed synthetic strategies for industrial and academic synthesis of HCQ and its key intermediates like 4,7-dichloroquinoline (4,7-DCQ) and 2-((4-aminopentyl)(ethyl)amino)ethan-1-ol 9 (aka hydroxynovaldiamine; HNDA). The review is expected to provide the right perspective of the state-of-the-art knowledge in this field so that further developments are possible.

Keywords: Hydroxychloroquine (HCQ), 4, 7-DCQ, HNDA, corona virus disease, Covid-19, toxic chloroquine.

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Article Details

(E-pub Ahead of Print)
DOI: 10.2174/1570193X18666210204113412
Price: $95

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