Background and Objective: Today, a new β-coronavirus called SARS-CoV-2 has emerged
and it is causing a global pandemic. Inter-human transmission studies have indicated a significant role
of aerosols in the transmission of many respiratory viruses. Hence, it is very important to decrease the
spread of the virus through disinfectant agents. This review aimed to provide an overview related to
possible alternative inhibitory molecules against this virus.
Method: The literature search was performed in the MEDLINE electronic database using the public
access known as NCBI-PUBMED. Keywords "coronavirus" and “SARS-CoV-2” and “COVID19”
were used. No specific time range was used.
Results: We provide a review related to structure, anti-coronavirus activity and molecular mechanism
of natural substances and semisynthetic derivatives such as glycopeptides, lipopeptides, probiotics,
surfactants, terpenes and resveratrol. We also include the latest in vitro experiments with anti-SARSCoV-
2 activity. We also provide the theoretical basis for discussing the prospects of such natural molecules
as possible alternative anti-Coronavirus products, so as to develop a complete screening for
Conclusion: In summary, this review suggest to investigate deeper several molecules most of which
belong to natural substances to fight COVID19 disease.