The Involvement of Histone Methylation in the Osteogenic Differentiation of Mesenchymal Stem Cells

Author(s): Lingyi Zhao, Bei Yin, Qingge Ma, Yu Shi, Chenglin Wang, Ling Ye*

Journal Name: Current Stem Cell Research & Therapy

Volume 16 , Issue 8 , 2021


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Abstract:

Bone is a hard but dynamic organ that is constantly remodeled throughout the life process. The dynamic balance between bone resorption and bone formation is very important. Mesenchymal stem cells (MSCs) have self-renewal and pluripotent differentiation; therefore, their roles as the promising tool for the treatment of osteoporosis and other diseases have become the focus in regenerative medicine in recent years. Over the past years, histone methylation has been recognized as a major player in the regulation of osteogenic differentiation of MSC. In this review, we highlight the recent research progress of histone methylation modification and its possible involvement in MSC osteogenesis.

Keywords: Cell differentiation, mesenchymal stem cells, epigenetics, osteogenesis, histone methylation, osteogenic differentiation.

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Article Details

VOLUME: 16
ISSUE: 8
Year: 2021
Published on: 02 February, 2021
Page: [915 - 923]
Pages: 9
DOI: 10.2174/1574888X16666210203110354
Price: $65

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