Sarcopenia is a commonly prevalent geriatric condition mainly characterized by progressive
loss of the skeletal muscle mass that results in noticeably reduced muscle strength and quality.
Most of the geriatric population above 60 years of age are overweight, leading to the accumulation
of fat in the muscles resulting in abated muscle function. The increased loss of muscle mass is associated
with high rates of disability, poor motility, frailty and mortality. The excessive degeneration
of muscles is now also being observed in middle-aged people. Therefore, geriatrics has recently
started shifting towards the identification of early stages of the disability in order to expand the life
span of the patient and reduce physical dependence. Recent findings have indicated that patients
with increased physical activity are also affected by sarcopenia, therefore indicating the role of nutritional
supplements to enhance muscle health which in turn helps to counteract sarcopenia. Various
interventions with physical training have not provided substantial improvements to this disorder,
thereby highlighting the crucial role of nutritional supplementation in enhancing muscle mass
and strength. Nutritional supplementation has not only been shown to enhance the positive effects
of physical interventions but also have a profound impact on the gut microbiome that has come forward
as a key regulator of muscle mass and function. This brief review throws light upon the efficiency
of nutrients and nutraceutical supplementation by highlighting their ancillary effects in physical
interventions as well as improving the gut microbiome status in sarcopenic adults, thereby giving
rise to a multimodal intervention for the treatment of sarcopenia.
Keywords: Ageing, cachexia, exercise, malnutrition, muscle mass, nutrition.
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