Promiscuous Biological Features of Newly Emerged SARS-CoV-2 Facilitate its Unrestrained Outbreak: An Update

(E-pub Ahead of Print)

Author(s): Asim Azhar*, Khaled Al-hosaini, Parvez Anwar Khan, Abdul M Oanz, Qamar Zia, Saeed Banawas, Jae-Jung Dong, Mohammad Amjad Kamal, Mohammad Owais

Journal Name: Coronaviruses
The World's First International Journal Dedicated to Coronaviruses


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Abstract:

The unrelenting protraction of Coronavirus Disease 2019 (COVID-19), inflicted by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), is tending to craft havoc all over the world for the past ten months. Keeping into consideration looming repercussions due to this deadly virus world over, there is an impending necessity to comprehend this newfangled contagion. To develop an effective eradication measure and preventive strategy, knowledge about the virus structure, life cycle, and metabolism is imperative. Better insight into the virus life cycle helps us to identify and design drugs that can hit crucial targets of this dreadful virus. The close genetic similarity between SARS-CoV-2 and SARS-CoV, which triggeredan outbreak in the year 2003, could be of great strategic importance in designing effective drug formulations. This will also help in leveraging immunological measures and development of leveraging immunological measures to develop an effective vaccine against SARS-CoV-2. This eventually will help us to progress our strategies to contain the virus. Not on the positive side, there is some misinformation going all around the world despite the strict regulations from the WHO and other government agencies to inform the citizens to abstain from the rumour-mongering to contain the COVID-19. Further, evidence needs to be gathered on vaccine strategies to cure the patients suffering from COVID-19. This information will also help us in designing both drug inhibitors as well as prophylactic measures against SARS-CoV-2.

Keywords: COVID-19, Corona Virus Disease, ACE 2, Angiotensin-Converting Enzyme 2, SARS, Severe Acute Respiratory Syndrome, MERS; Middle East Respiratory Syndrome, SARS-CoV, SARS Coronaviruses

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Article Details

(E-pub Ahead of Print)
DOI: 10.2174/2666796702666210202125638