In December 2019, a new severe acute respiratory coronavirus (SARS- COV-2) had caused outbreaks of pneumonia in Wuhan city, China. It was known as coronavirus infected disease-2019 (COVID-19). COVID-19 patients are typically have fever and respiratory syndrome, where the lung is the main target organ affected by this virus. The objective of this review is to monitor and evaluate injuries caused by SARS-COV-2 virus on multiple organs other than lung as gastrointestinal tract, liver, kidney, heart, ovary, ocular, olfactory, gonad, skin, central nervous system and sense organs. As SARS- COV-2 virus enters host cells via cell receptor angiotensin circulating enzyme-2 (ACE2), so it is important to identify the main target cells attacked by SARS- COV-2 virus through comparing the ACE2 expression and viral upload in different organs. In conclusion, explore the definite role of body organs in manifestation of COVID-19 infection and crosstalk between different organs are good tools to find any correlation between disease severity and organs dysfunction, exact prognosis, disease prevention measures, clinical care and treatment strategies.