In Vivo Evaluation of Inorganic Nanoparticle Complexes against CCL4 Induced Hepatotoxicity

(E-pub Ahead of Print)

Author(s): Rabia Tabbasam, Sana Khursid*, Yasmeen Ishaq, Arif Malik

Journal Name: Current Drug Delivery

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Background: Combination of different chemotherapy drugs and nanoparticles as a carrier have shown promising delivery system in cancer treatment. Doxorubicin is considered as a potent anticancer drug. However, it’s off target activities and possible side effects, make its use limited. Recently, in the field of nanomedicine, different nanoconjugates have been developed as a unique platform for the delivery of therapeutic drugs.

Objective: The aim of present study was to evaluate the best possible combination for efficient delivery of DOX with combination of gold, silver and zinc oxide nanoparticles to target site against carbon tetrachloride induced rat hepatotoxicity.

Methodology:Effect of different conjugates administrated for 14 consecutive days was evaluated. Results: In comparison to DOX, Au:DOX, ZnoO:DOX and Ag:DOX showed less sign of liver fibrosis as evaluated by serum enzymes and histo-pathological analysis. However, among all the conjugates, Ag: DOX conjugate showed most significant results. The serum alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase values were (111.2 ± 38.21, 323.2 ± 46.88 and 303.6 ± 73.80 respectively) very close to control group (72.2 ± 19.41, 368 ± 59.78 and 259.4 ± 61.54 respectively).

Conclusion:Our results demonstrated that Ag: DOX may exhibit hepato-protective activity against CCl4 induced liver damage.

Keywords: Combination, Drug Delivery, Nanoparticles, CCL4, Hepatoprotective, Nano conjugate, Doxorubicin

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Article Details

(E-pub Ahead of Print)
DOI: 10.2174/1567201818666210202105531
Price: $95

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