Background: Pro-inflammatory mediators and oxidative stress are related to the severity of
angina pectoris in patients with coronary heart disease.
Objective: We evaluated the effects of pro-inflammatory mediators and oxidative stress on recurrent
angina pectoris after coronary artery stenting in elderly patients.
Methods: We determined the expression levels of malondialdehyde (MDA), acrolein (ACR), tumour
necrosis factor-α (TNF-α), toll-like receptor 4 (TLR4), superoxide dismutase 3 (SOD3), paraoxonase-1
(PON-1), stromal cell-derived factor-1α (SDF-1α) and endothelial progenitor cells (EPCs) in elderly
patients with recurrent angina pectoris after coronary artery stenting.
Results: Levels of MDA, ACR, TNF-α and TLR4 were significantly increased (p<0.001), and levels of
SOD3, PON-1, SDF-1α and EPCs were significantly decreased (p<0.001) in the elderly patients with
recurrent angina pectoris after coronary artery stenting. MDA, ACR, TNF-α and TLR4 as markers of
oxidative stress and pro-inflammatory mediators may have suppressed SOD3, PON-1, SDF-1α and
EPCs as markers of anti-oxidative stress/anti-inflammatory responses. Oxidative stress and proinflammatory
mediators were important factors involved in recurrent angina pectoris of elderly patients
after coronary artery stenting.
Conclusion: Oxidative stress and pro-inflammatory mediators could be considered as potential noninvasive
prognostic, predictive, and therapeutic biomarkers for stable recurrent angina and recurrent
unstable angina in elderly patients after coronary artery stenting.