Background: Brazilian flora is rich in plants with medicinal properties, which though
popular, has contributed to the development of a range of phytotherapic products that use plants to
treat and cure diseases. However, studies that use Brazilian plants in the treatment of metabolic disorders
are still scarce in the literature.
Objective: The aim of this study was to analyze the effect of hepatotoxicity Lafoensia pacari on
the metabolism of mice with obesity induced by a high-fat diet and to verify the phytochemical difference
between the Lafoensia pacari bark of the trunk, leaves, and branches.
Methods: The plant material was collected from April to May in the municipality of Bonito de Minas,
MG, Brazil. Qualitative tests for the presence of secondary metabolite classes were performed
for leaves, branches and bark of the trunk. Through histological analysis, we evaluated hepatocytes
and cell lesions in the liver.
Results: The comparative phytochemical analysis of the plant did not reveal alterations between
the different plant parts. The phytochemical test showed that is preferable to use the leaves to make
the extract to be applied, aiming to reduce the plant aggression. After treatment, greater changes
were observed in the animals that received the high-fat diet and the hydroethanolic extract; the levels
of AST, ALT, albumin and creatinine that were increased, thus demonstrating a possible toxicity.
There were no significant differences in body weight. In the histological analysis, the animals
without plant treatment displayed decreased liver weight and reduction in the inflammatory infiltrate.
Conclusion: We conclude that Lafoensia pacari should be better evaluated for oral consumption
and may cause liver damage.