Coronavirus-19 causing a severe acute respiratory disorder in humans and becoming a major health problem. Its expansion takes place very rapidly throughout the world since it has been first identified in Wuhan, China (December 2019). The causative virus is known as severe acute respiratory syndrome coronavirus 2. And the World Health Organization has named this respiratory syndrome as a new epidemic disease called COVID-19. The incidence of COVID-19 continues to increase with three million confirmed infected cases and with 244,000 death cases worldwide. Still, now there is no specific treatment or vaccine available against COVID- 19. The collective information about the different aspects of COVID-19 viral infection has gathered from renowned journals, and electronic databases including Science Direct, Web of Science, Scopus and PubMed from 1990 to 2020 The current manuscript has highlighted transmission and symptoms. Therefore, the current manuscript also included says how the SARS-CoV 2 can facilitate the debut of the virus into targeted host cells.