Cardiovascular Diseases (CVD) remain the leading cause of mortality and morbidity worldwide. To date,
significant progress has been made in developing stimuli-responsive nanosystems that can intrinsically interact with
pathological microenvironment to achieve site-specific delivery along with on-demand drug release for precise CVD
treatment. Herein, this review summarizes recent advances on smart nanosystems in response to a wide range of biological
cues, including pH, enzymes, ROS, shear force, ATP, etc., which can boost drug delivery performance or monitor disease
progression in a non-invasive manner. The designs, compositions and main outcomes of the single and multi- responsive
nanosystems for drug delivery and/or detection purposes are provided and discussed.