Biologically Responsive Nanosystems Targeting Cardiovascular Diseases Therapy

(E-pub Ahead of Print)

Author(s): Zhiling Song, Kechen Song, Yi Xiao, Hui Guo, Yizhun Zhu*, Xiaolin Wang*

Journal Name: Current Drug Delivery


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Abstract:

Cardiovascular Diseases (CVD) remain the leading cause of mortality and morbidity worldwide. To date, significant progress has been made in developing stimuli-responsive nanosystems that can intrinsically interact with pathological microenvironment to achieve site-specific delivery along with on-demand drug release for precise CVD treatment. Herein, this review summarizes recent advances on smart nanosystems in response to a wide range of biological cues, including pH, enzymes, ROS, shear force, ATP, etc., which can boost drug delivery performance or monitor disease progression in a non-invasive manner. The designs, compositions and main outcomes of the single and multi- responsive nanosystems for drug delivery and/or detection purposes are provided and discussed.

Keywords: Biologically responsive, nanosystems, nanoparticle, drug delivery, stimuli-triggered drug release, cardiovascular diseases.

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Article Details

(E-pub Ahead of Print)
DOI: 10.2174/1567201818666210127093743
Price: $95