Background: Aging is associated with most neurodegenerative disorders such as Parkinson's and Alzheimer's
diseases. Determination of peripheral blood biomarkers represents a low invasive approach for tracking early changes in
body metabolism during aging.
Objectives: This study addresses a cross-sectional analysis to identity changes in lipid, minerals and antioxidant capacity
as potential biomarkers to the onset of neurodegenerative diseases during aging.
Methods: A retrospective analysis was performed to determine age-related biomarkers from a clinical sample database.
Next, one hundred volunteers between 20-59 (adult) and over 60 years (elderly) were submitted to motor and cognitive
tests according to Unified Parkinson's Disease Rating Scale (UPDRS) and Mini Mental State Examination (MMSE)
respectively. Peripheral blood samples were also collected to determine circulating lipids, minerals and antioxidant
Results: Lipid profile revealed an increase in Triglycerides, Total and VLDL Cholesterol. Among elderly, HDL was
lower than adult group, particularly in volunteers with severe cognitive decline. Minerals involved in antioxidant defense
such as Iron, Selenium and Manganese were lower in elderly compared to adults. Catalase activity was also reduced
among elderly with mild cognitive impairment.
Conclusion: Here we show changes in key serum biomarkers correlates with aging and clinical cognitive decline among
elderly. These findings may contribute to the understanding how biomarkers can be useful for early diagnosis and
treatment of aging-related diseases.