Changes in Peripheral Blood Biomarkers with Aging and Neurodegenerative Disorders

(E-pub Ahead of Print)

Author(s): Marcela Lima, Cezar Pestana*

Journal Name: Current Aging Science


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Abstract:

Background: Aging is associated with most neurodegenerative disorders such as Parkinson's and Alzheimer's diseases. Determination of peripheral blood biomarkers represents a low invasive approach for tracking early changes in body metabolism during aging.

Objectives: This study addresses a cross-sectional analysis to identity changes in lipid, minerals and antioxidant capacity as potential biomarkers to the onset of neurodegenerative diseases during aging.

Methods: A retrospective analysis was performed to determine age-related biomarkers from a clinical sample database. Next, one hundred volunteers between 20-59 (adult) and over 60 years (elderly) were submitted to motor and cognitive tests according to Unified Parkinson's Disease Rating Scale (UPDRS) and Mini Mental State Examination (MMSE) respectively. Peripheral blood samples were also collected to determine circulating lipids, minerals and antioxidant capacity.

Results: Lipid profile revealed an increase in Triglycerides, Total and VLDL Cholesterol. Among elderly, HDL was lower than adult group, particularly in volunteers with severe cognitive decline. Minerals involved in antioxidant defense such as Iron, Selenium and Manganese were lower in elderly compared to adults. Catalase activity was also reduced among elderly with mild cognitive impairment.

Conclusion: Here we show changes in key serum biomarkers correlates with aging and clinical cognitive decline among elderly. These findings may contribute to the understanding how biomarkers can be useful for early diagnosis and treatment of aging-related diseases.

Keywords: Neurodegeneration, aging, biomarkers, hypercholesterolemia, antioxidants.

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Article Details

Published on: 26 January, 2021
(E-pub Ahead of Print)
DOI: 10.2174/1874609814666210127090100
Price: $95

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