Login Register Cart 0
Generic placeholder image

Recent Patents on Biotechnology

Editor-in-Chief

ISSN (Print): 1872-2083
ISSN (Online): 2212-4012

Back
Journal Home About Journal Editorial Board Journal Insight Current Issue Volumes/Issues
Subscribe
Mini-Review Article

Patents Related to Pathogenic Human Coronaviruses

Author(s): Michelli dos Santos, André V.F. Ferreira, Jonatas O. da Silva, Laís M. Nogueira, Juliana M. Machado, Mariana F.C. Francisco, Mariana C. da Paz, Rodolfo C. Giunchetti and Alexsandro S. Galdino*

Volume 15, Issue 1, 2021

Published on: 27 January, 2021

Page: [12 - 24] Pages: 13

DOI: 10.2174/1872208315666210127085404

Price: $65

Abstract

Background: Coronaviruses have caused outbreaks of respiratory disease since the beginning of the 21st century, representing a significant threat to public health. Together, the severe acute respiratory syndrome coronavirus (SARS-CoV), the respiratory syndrome coronavirus (MERS-CoV), and, more recently, the novel coronavirus (SARS-CoV-2) have caused a large number of deaths around the world. Thus, investments in research and the development of strategies aimed at diagnosing, treating, and preventing these infections are urgently needed.

Objective: The objective of this study was to analyze the patents that address pathogenic coronaviruses in Google Patents databases in the last year (2019-2020).

Methods: The search strategy was carried out in April 2020, based on the keywords “SARS”, “SARS-CoV”, “MERS”, “MERS-CoV”, “SARS-CoV-2” and “COVID-19. Out of the patents examined, 25 were selected for a short description in this study.

Results: A total of 191 patents were analyzed, 149 of which were related to SARS-CoV, and 29 and 12 were related to MERS-CoV and SARS- CoV2, respectively. The patents addressed the issues of diagnosis, therapeutic agents, prevention and control, along with other applications.

Conclusion: Several promising strategies have been documented in intellectual property databases favoring the need for further studies on the pathogenesis and optimization of the diagnosis and therapeutic treatment for these emerging infections.

Keywords: Coronaviruses, COVID-19, HCoVs, MERS, pandemic, patents, SARS.

« Previous Next »
Graphical Abstract

[1]
Totura AL, Bavari S. Broad-spectrum coronavirus antiviral drug discovery. Expert Opin Drug Discov 2019; 14(4): 397-412.
[http://dx.doi.org/10.1080/17460441.2019.1581171] [PMID: 30849247]
[2]
Yu P, Hu B, Shi ZL, Cui J. Geographical structure of bat SARS-related coronaviruses. Infect Genet Evol 2019; 69: 224-9.
[http://dx.doi.org/10.1016/j.meegid.2019.02.001] [PMID: 30735813]
[3]
Su S, Wong G, Shi W, et al. Liu J, Lai ACK, Zhou J, etal Epidemiology, genetic recombination, and pathogenesis of coronaviruses. Trends Microbiol 2016; 24(6): 490-502.
[http://dx.doi.org/10.1016/j.tim.2016.03.003] [PMID: 27012512]
[4]
Yang Y, Peng F, Wang R, et al. The deadly coronaviruses: the 2003 SARS pandemic and the 2020 novel coronavirus epidemic in China. J Autoimmun 2020; 109: 102434.
[http://dx.doi.org/10.1016/j.jaut.2020.102434] [PMID: 32143990]
[5]
Banerjee A, Kulcsar K, Misra V, Frieman M, Mossman K. Bats and coronaviruses. Viruses 2019; 11(1): 41.
[http://dx.doi.org/10.3390/v11010041] [PMID: 30634396]
[6]
Ye Z-W, Yuan S, Yuen K-S, Fung SY, Chan CP, Jin DY. Zoonotic origins of human coronaviruses. Int J Biol Sci 2020; 16(10): 1686-97.
[http://dx.doi.org/10.7150/ijbs.45472] [PMID: 32226286]
[7]
de Wit E, van Doremalen N, Falzarano D, Munster VJ. SARS and MERS: recent insights into emerging coronaviruses. Nat Rev Microbiol 2016; 14(8): 523-34.
[http://dx.doi.org/10.1038/nrmicro.2016.81] [PMID: 27344959]
[8]
Wong G, Liu W, Liu Y, Zhou B, Bi Y, Gao GF. MERS, SARS, and Ebola: the role of super-spreaders in infectious disease. Cell Host Microbe 2015; 18(4): 398-401.
[http://dx.doi.org/10.1016/j.chom.2015.09.013] [PMID: 26468744]
[9]
Al-Tawfiq JA, Zumla A, Memish ZA. Travel implications of emerging coronaviruses: SARS and MERS-CoV. Travel Med Infect Dis 2014; 12(5): 422-8.
[http://dx.doi.org/10.1016/j.tmaid.2014.06.007] [PMID: 25047726]
[10]
World Health Organization. Summary of probable SARS cases with onset of illness from 1 November 2002 to 31 July 2003. https://www.who.int/csr/sars/country/table2004_04_21/en/2020.
[11]
de Wilde AH, Snijder EJ, Kikkert M, van Hemert MJ. Host factors in coronavirus replication. Curr Top Microbiol Immunol 2018; 419: 1-42.
[PMID: 28643204]
[12]
Cui J, Li F, Shi ZL. Origin and evolution of pathogenic coronaviruses. Nat Rev Microbiol 2019; 17(3): 181-92.
[http://dx.doi.org/10.1038/s41579-018-0118-9] [PMID: 30531947]
[13]
Al-Hazmi A. Challenges presented by MERS corona virus, and SARS corona virus to global health. Saudi J Biol Sci 2016; 23(4): 507-11.
[http://dx.doi.org/10.1016/j.sjbs.2016.02.019] [PMID: 27298584]
[14]
World Health Organization. Middle East respiratory syndrome coronavirus (MERS-CoV). 2020 Available at: https://www.who.int/emergencies/mers-cov/en/
[15]
Abuhammad A, Al-Aqtash RA, Anson BJ, Mesecar AD, Taha MO. Computational modeling of the bat HKU4 coronavirus 3CLpro inhibitors as a tool for the development of antivirals against the emerging Middle East respiratory syndrome (MERS) coronavirus. J Mol Recognit 2017; 30(11): e2644.
[http://dx.doi.org/10.1002/jmr.2644] [PMID: 28608547]
[16]
Trindade GG, Caxito SMC, Xavier AREO, Xavier MAS, BrandÃo F. COVID-19: therapeutic approaches description and discussion. An Acad Bras Cienc 2020; 92(2): e20200466.
[http://dx.doi.org/10.1590/0001-3765202020200466] [PMID: 32556054]
[17]
Lu H, Stratton CW, Tang YW. Outbreak of pneumonia of unknown etiology in Wuhan, China: the mystery and the miracle. J Med Virol 2020; 92(4): 401-2.
[http://dx.doi.org/10.1002/jmv.25678] [PMID: 31950516]
[18]
Huang C, Wang Y, Li X, et al. Ren L, Zhao J, Hu Y, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet 2020; 395(10223): 497-506.
[http://dx.doi.org/10.1016/S0140-6736(20)30183-5] [PMID: 31986264]
[19]
World Health Organization Coronavirus disease (COVID-19) pandemic. 2020 Available at: https://www.who.int/emergencies/diseases/novel-coronavirus-2019
[20]
Sohrabi C, Alsafi Z, O’Neill N, et al. Khan M, Kerwan A, Al-Jabir A, et al. World Health Organization declares global emergency: a review of the 2019 novel coronavirus (COVID-19). Int J Surg 2020; 76: 71-6.
[http://dx.doi.org/10.1016/j.ijsu.2020.02.034] [PMID: 32112977]
[21]
Chen S, Zhang Z, Yang J, et al. Wang J, Zhai X, Bärnighausen T et al. Fangcang shelter hospitals: a novel concept for responding to public health emergencies. Lancet 2020; 395(10232): 1305-14.
[22]
Nogueira L, et al. O envolvimento da Ciência Brasileira no diagnóstico da COVID-19. Ciência em Movimento 2020; 22(43): 161.
[http://dx.doi.org/10.15602/1983-9480/cm.v22n43p161-178]
[23]
Decaro N, Lorusso A. Novel human coronavirus (SARS-CoV-2): a lesson from animal coronaviruses. Vet Microbiol 2020; 244: 108693.
[http://dx.doi.org/10.1016/j.vetmic.2020.108693] [PMID: 32402329]
[24]
Zhou P, Yang XL, Wang XG, et al. Hu B, Zhang L, Zhang W, et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature 2020; 579(7798): 270-3.
[http://dx.doi.org/10.1038/s41586-020-2012-7] [PMID: 32015507]
[25]
Lam TTY, Jia N, Zhang YW, et al. Shum MH, Jiang JF, Zhu HC et al. Identifying SARS-CoV-2-related coronaviruses in Malayan pangolins. Nature 2020; 583(7815): 282-5.
[http://dx.doi.org/10.1038/s41586-020-2169-0] [PMID: 32218527]
[26]
Kim YK, Jeong GH, Gesture H, et al. Son H-S, Kim K-D, Kim J-S, et al. Method and kit for detecting batcoronavirus using real-time PCR. KR102018201B1, 2019.
[27]
Hui X, Xiangsheng Y, Tengfei P, Yiying Y. For detecting the kit of the respiratory pathogen of community acquired pneumonia. CN109988867A, 2019.
[28]
Xiwen J, Hongxia J, Jian F. Novel coronavirus N gene nucleic acid detection kit. CN111004870A, 2020.
[29]
Lizhong D, Deyong T, Zhongping D, et al. Composition, kit and method for detecting and typing coronavirus and application thereof. CN110982942A, 2020.
[30]
Jianwei W, Lili R, Yan X, Li G, Jianguo L. Fluorescent quantitative PCR detection method for human coronavirus and respiratory syncytial virus and application thereof. CN110724764A, 2019.
[31]
Di X. A kind of PCR (polymerase chain reaction) amplification and terminal visible detection method. CN109706228A, 2019.
[32]
Hao S. Array type paper-based chip capable of being used for 2019-nCoV virus high-throughput detection and manufacturing method thereof. CN110951605, 2020.
[33]
Ling C, Chenchen Y, Xiaolin L. Nucleic acid sequence for expressing SARS-CoV-2 virus antigen peptide and its application. CN110951756A, 2020.
[34]
Kim D, Yunji K, Geun-Wan P, et al. Monoclonal antibodies of specifically binding to spike S2 protein of MERS-CoV. KR101969696B1, 2019.
[35]
Sam H. A method for detecting MERS coronavirus using MERS coronavirus nucleocapsid fusion protein. KR102019008B1, 2019.
[36]
Jo HJ. Mideast respiratory syndrome and severe acute respiratory syndrome biomarkers and candidate compounds for the development of MERS cure. KR20200007980A, 2020.
[37]
Kim K, Kim M, Kim W, Young GY. Novel nucleoside or nucleotide derivatives, and use thereof. KR20200021494A, 2020.
[38]
Kim S. CoVID-19 suitable triple knockout DNAi remedy. KR20200032050A, 2020.
[39]
Xiaotao D, Xuemin Z, Bingjie Q, Nan S, Qi Q. Application of the aminoglucose carbohydrates and their derivative as antiviral drugs. CN109771432A, 2019.
[40]
Walker DM, Kajon AE, Walker VE. Broad spectrum antiviral and methods of use. US20200093841A1, 2020.
[41]
Chao W, Yue L. MERS-CoV fusion inhibitor. CN110128510A, 2019.
[42]
Yong-Suk J, Joo K. A composition for preventing or treating MERS-CoV virus comprising HBD2 (human beta-defensin 2) or an fusion protein comprising epitope protein of MERS-CoV virus and the HBD2). KR20190134578A, 2019.
[43]
Shin JN, Shin Y, Yoon J, et al. Posthumous PK. Carbocyclic nucleosides derivatives and the antivirus compositions containing the same. KR20190117442A, 2019.
[44]
Youwen G. Prescription for treating pneumonia infected by novel coronavirus and application thereof. CN10870402A, 2020.
[45]
Yun H, Yihua Z. A kind of compound disinfectant based on QUAT12 degerming factor. CN110352992A, 2019.
[46]
Chengcheng Y. Medical self-disinfection logistics robot and control method thereof. CN110948505A, 2020.
[47]
Guanhua L, Dan Y, Zhe Z, Qinglong D, Xueji Z. Epidemic situation monitoring method and system based on wearable body temperature sensor. CN110926655A, 2020.
[48]
Longtao W, Lijun C, Baoxiang S, Yafei W, Shuangquan L. Multifunctional filtering material and preparation method thereof. CN110812948A, 2020.
[49]
Yuhuan M, Yujia G, Hui Y. Method and device for detecting human genome virus integration site. CN110957008A, 2020.
[50]
Chang-Gyu S, Kang SH, Kim S, Kim KH. 4-person ward structure with private area and independent windows. KR20200032054A, 2020.
[51]
Long C, Xu H, Shen Q, et al. Zhang X, Fan B, Wang C et al. Diagnosis of the Coronavirus disease (COVID-19): rRT-PCR or CT? Eur J Radiol 2020; 126: 108961.
[http://dx.doi.org/10.1016/j.ejrad.2020.108961] [PMID: 32229322]
[52]
Calvo C, López-Hortelano MG, Vicente JC, De C, Martínez JLV. Recommendations on the clinical management of the COVID-19 infection by the new coronavirus SARS-CoV2. Pediatria (Napoli) 2020; 92(4): 241.e1-241.e11.
[53]
Zheng Z, Yao Z, Wu K, Zheng J. The diagnosis of pandemic coronavirus pneumonia: a review of radiology examination and laboratory test. J Clin Virol 2020; 128: 104396.
[http://dx.doi.org/10.1016/j.jcv.2020.104396] [PMID: 32438256]
[54]
Zumla A, Chan JF, Azhar EI, Hui DS, Yuen KY. Coronaviruses - drug discovery and therapeutic options. Nat Rev Drug Discov 2016; 15(5): 327-47.
[http://dx.doi.org/10.1038/nrd.2015.37] [PMID: 26868298]
[55]
Li H, Liu SM, Yu XH, Tang SL, Tang CK. Coronavirus disease 2019 (COVID-19): current status and future perspectives. Int J Antimicrob Agents 2020; 55(5): 105951.
[http://dx.doi.org/10.1016/j.ijantimicag.2020.105951] [PMID: 32234466]
[56]
Kang S, Peng W, Zhu Y, et al. Lu S, Zhou M, Lin W, et al. Recent progress in understanding 2019 novel coronavirus (SARS-CoV-2) associated with human respiratory disease: detection, mechanisms and treatment. Int J Antimicrob Agents 2020; 55(5): 105950.
[http://dx.doi.org/10.1016/j.ijantimicag.2020.105950] [PMID: 32234465]
[57]
Khan S, Siddique R, Shereen MA, et al. Ali A, Liu J, Bai Q, et al. Emergence of a novel coronavirus, severe acute respiratory syndrome coronavirus 2: biology and therapeutic options. J Clin Microbiol 2020; 58(5): e00187-20.
[http://dx.doi.org/10.1128/JCM.00187-20] [PMID: 32161092]
[58]
Fung TS, Liu DX. Post-translational modifications of coronavirus proteins: roles and function. Future Virol 2018; 13(6): 405-30.
[http://dx.doi.org/10.2217/fvl-2018-0008] [PMID: 32201497]
[59]
Colson P, Raoult D. Fighting viruses with antibiotics: an overlooked path. Int J Antimicrob Agents 2016; 48(4): 349-52.
[http://dx.doi.org/10.1016/j.ijantimicag.2016.07.004] [PMID: 27546219]
[60]
Bleibtreu A, et al. Jaureguiberry S, Houhou N, Boutolleau D, Guillot H, Vallois D et al. Clinical management of respiratory syndrome in patients hospitalized for suspected Middle East respiratory syndrome coronavirus infection in the Paris area from 2013 to 2016. Infect Dis 2016; 18(1): 331.
[61]
Wang SX, Wang Y, Lu YB, et al. , Li JY, Song YJ, Nyamgerelt M, et al. Diagnosis and treatment of novel coronavirus pneumonia based on the theory of traditional Chinese medicine. J Integr Med 2020; 18(4): 275-83.
[http://dx.doi.org/10.1016/j.joim.2020.04.001] [PMID: 32446813]
[62]
Powell-Jackson T, King JJC, Makungu C, et al. Spieker N, Woodd S, Risha P, et al. Infection prevention and control compliance in Tanzanian outpatient facilities: a cross-sectional study with implications for the control of COVID-19. Lancet Glob Health 2020; 8(6): e780-9.
[http://dx.doi.org/10.1016/S2214-109X(20)30222-9] [PMID: 32389195]
[63]
Otter JA, Donskey C, Yezli S, Douthwaite S, Goldenberg SD, Weber DJ. Transmission of SARS and MERS coronaviruses and influenza virus in healthcare settings: the possible role of dry surface contamination. J Hosp Infect 2016; 92(3): 235-50.
[http://dx.doi.org/10.1016/j.jhin.2015.08.027] [PMID: 26597631]
[64]
Robson B. Computers and viral diseases. Preliminary bioinformatics studies on the design of a synthetic vaccine and a preventative peptidomimetic antagonist against the SARS-CoV-2 (2019-nCoV, COVID-19) coronavirus. Comput Biol Med 2020; 119: 103670.
[http://dx.doi.org/10.1016/j.compbiomed.2020.103670] [PMID: 32209231]
[65]
Chen Y, Liu Q, Guo D. Emerging coronaviruses: genome structure, replication, and pathogenesis. J Med Virol 2020; 92(4): 418-23.
[http://dx.doi.org/10.1002/jmv.25681] [PMID: 31967327]
[66]
Chen X, Lu L, Shi J, et al. Zhang X, Fan H, Fan B, et al. Application and prospect of a mobile hospital in disaster response. Disaster Med Public Health Prep 2020; 14(3): 377-83.
[http://dx.doi.org/10.1017/dmp.2020.113] [PMID: 32317031]
[67]
Liu YC, Kuo RL, Shih SR. COVID-19: the first documented coronavirus pandemic in history. Biomed J 2020; 43(4): 328-33.
[http://dx.doi.org/10.1016/j.bj.2020.04.007] [PMID: 32387617]

Rights & Permissions Print Cite
Article Metrics
52
1
© 2024 Bentham Science Publishers | Privacy Policy