Epigenetic Regulation and Promising Therapies in Colorectal Cancer

(E-pub Ahead of Print)

Author(s): Chandra Kishore*

Journal Name: Current Molecular Pharmacology

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The recent developments in epigenetics have shown a very important role of epigenetic changes in cancer initiation, development, and progression. Some of the important histone modifications shown to occur are methylation, acetylation, phosphorylation, citrullination, sumoylation, ADP ribosylation, deamination, ubiquitination, formylation, O-GlcNAcylation, propionylation, butyrylation, proline isomerization, and crotonylation but most of the studies in past had limited their studies mainly on histone methylation, acetylation, and phosphorylation. Modification of DNA strand by hypermethylation and hypomethylation regulates genomic instability and promotes cancer. Colorectal cancer involves multiple changes in epigenetic marks present on histone residues and DNA, which in collaboration with genetic changes, drives cancer progression. In this review paper, basic concepts of epigenetics relevant to cancer development are discussed followed by its significance in understanding the mechanism of colon carcinogenesis. Some of the epigenetic target based drugs are also discussed in the relevant sections to give an idea of the potential promises of epigenetics for colorectal cancer treatment.

Keywords: Colorectal cancer, histone modification, DNA methylation, epigenetic therapy, epigenetic marks, epigenetic crosstalk, Epigenetic signaling, posttranslational modifications

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Article Details

Published on: 25 January, 2021
(E-pub Ahead of Print)
DOI: 10.2174/1874467214666210126105345
Price: $95

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