Visible Light Mediated, Catalyst Free, One-Pot Convenient Synthesis of Dihydropyridines

(E-pub Ahead of Print)

Author(s): Jia-Qi Di, Meng-Nan Chen, Ai-Dong Zhao*, Zhan-Hui Zhang*

Journal Name: Letters in Organic Chemistry


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Abstract:

A simple, efficient and green protocol has been developed for the synthesis of polysubstituted dihydropyridines via one-pot, four-component reaction of aldehydes, arylamines, dialkyl acetylenedicarboxylate, and malononitrile. The reaction was proceeded at room temperature in the absence of catalyst in aqueous ethyl lactate under visible light irradiation. The main advantages of the present approach are mild reaction condition, high yield, no column chromatography, clean reaction profile, environmentally friendly and sustainable from the economic point of view.

Keywords: catalyst-free, dihydropyridine, green chemistry, multi-component reaction, visible light

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Article Details

Published on: 25 January, 2021
(E-pub Ahead of Print)
DOI: 10.2174/1570178618666210125162342
Price: $95

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