Background: Pain not only affects the quality of life of an individual but can also cause
mental illness due to the lack of effective treatment for long-term pain. Analgesics refer to drugs
that can partially or completely relieve pain, including non-steroidal anti-inflammatory drugs and
Methods: In recent years, the cross integration of electrochemical analysis technology with biochemistry,
materials science, biomedicine and other disciplines has driven the vigorous development
of electrochemical sensing technology in the field of life sciences. The electrochemical sensor
has many advantages, such as simple equipment, good specificity, high sensitivity, economy
and convenience. As a newly emerging technology, electrochemical sensing technology has been
increasingly used in drug analysis.
Results: This review introduces the recent advances of the detection of analgesics using electrochemical
technology. We deliberately selected three representative drugs for discussion: aspirin,
ibuprofen and paracetamol.
Conclusion: Electrochemical sensing technology has the advantages of high sensitivity, a low detection
limit and simple operation. However, sensors still have some technical problems, such as
the existence of many interference factors in actual samples in blood drug concentration monitoring
and the need to further optimize the method conditions for multi-channel detection. With the
continuous advancement of research, the application of new detection methods, nanomaterials, and
biomolecules has enabled electrochemical technology to make certain progress in the field of drug
analysis. In particular, the emergence of new nanomaterials will greatly promote the development
of electrochemical sensing technology in drug analysis. As a cutting-edge technology, electrochemical
sensing technology has enormous potential application value.