Effect of Type 2 Diabetes Mellitus and Diabetic Medication on Pulmonary Function

Author(s): Alaa M. Hammad*, Walid Al-Qerem, Ameen Alassi, Dana Hyassat

Journal Name: Current Respiratory Medicine Reviews

Volume 16 , Issue 4 , 2020

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Graphical Abstract:


Background: Type 2 diabetes mellitus (T2DM) is a chronic condition with an impairing effect on multiple organs. Numerous respiratory disorders have been observed in patients with T2DM. However, the effect of T2DM on pulmonary function is inconclusive.

Aims: In this study, we investigated the effect of T2DM on respiratory function and the correlation of glycemic control, diabetes duration and insulin intake.

Methods: 1500 patients were recruited for this study; 560 having T2DM for at least a year were included in the final data, in addition to 540 healthy volunteers. Forced expiratory volume in one second (FEV1), forced vital capacity (FVC), forced expiratory flow at 25-75% (FEF 25-75%), as well as FEV1/FVC ratio values were measured.

Results: A two-sample t-test showed that z-scores produced by Al-Qerem et al.’s equations for FEV1, FVC, and FEF 25-75% were significantly lower for the T2DM group than the control group (p < 0.01). FEV1/FVC ratio in the T2DM group was significantly higher (p < 0.01). Multiple linear regression analysis found that glycemic control represented by HbA1c as well as disease duration were negatively associated with the pulmonary function (p < 0.01). However, insulin intake was found to have no significant correlation with pulmonary function.

Conclusion: T2DM was linked to reduced pulmonary function and was consistent with a restrictive ventilation pattern. HbA1c, as well as disease duration, were found to be independent risk factors for reduced pulmonary function.

Keywords: Diabetes, FVC, FEV1, HbA1c, T2DM, FEV1.

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Article Details

Year: 2020
Published on: 01 March, 2021
Page: [213 - 219]
Pages: 7
DOI: 10.2174/1573398X17666210121141412
Price: $65

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