A Review of Light Sources and Enhanced Targeting for Photodynamic Therapy

Author(s): Menghua Xiang, Quanming Zhou, Zihan Shi, Xuan Wang, Mengchu Li, Yan Jia, Shaoyun Li, Fen Yang, Wei Wang, Tongkai Chen, Xiaojun Xu, Bigyan Sharma, Yichu Nie, Qicai Xiao*, Liqian Gao*

Journal Name: Current Medicinal Chemistry

Volume 28 , Issue 31 , 2021


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Abstract:

Photodynamic Therapy (PDT), as a clinically approved modality for the treatment of various disordered diseases including cancer, has received great advances in recent years. By preferentially accumulating non-toxic Photosensitizers (PSs) in the pathological area, and in situ generation of cytotoxic reactive oxygen species (ROS) under local irradiation by a light source with appropriate wavelength, PDT works in a dual-selective manner. Over the past decades, numerous studies and reviews on PDT mainly focused on activable PSs and the newly emerging PSs in PDT. However, to the best of our knowledge, there are few articles on the systematic introduction of light sources and limited reports about targeted strategies in PDT. This review comprehensively summarizes various light sources applied in PDT together with typical enhanced targeting strategies, and outlines their advantages and disadvantages, respectively. The clinical applications and future perspectives in light sources are also partly presented and discussed.

Keywords: Photodynamic therapy, photosensitizers, reactive oxygen species (ROS), light source, oncotherapy, targeting.

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Article Details

VOLUME: 28
ISSUE: 31
Year: 2021
Published on: 21 January, 2021
Page: [6437 - 6457]
Pages: 21
DOI: 10.2174/0929867328666210121122106
Price: $65

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