A Review on Pancreatic Lipase Inhibitors from Natural Sources: A Potential Target for Obesity

Author(s): Bency Baby T*, Murali R, Suriyaprakash TNK, Srinivasan N

Journal Name: Current Enzyme Inhibition

Volume 17 , Issue 2 , 2021

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Graphical Abstract:


Background: Obesity is a worldwide lifestyle disorder and its incidence is growing at an alarming rate. Pancreatic lipase (PL) plays a key role in lipid metabolism and hence is a potential target for obesity treatment. There have been reports that many bioactive compounds from natural sources constitute a vast pool of PL inhibitors.

Objective: In search of natural pancreatic lipase inhibitors, the review summarizes the potential of natural products for their pancreatic lipase inhibitory activity.

Methods: In this review, the data obtained from literature search of various electronic databases and journal article publications have been reviewed.

Results: The pancreatic lipase inhibitory activities of 61 biological sources reviewed in this paper are backed by preclinical experimental evidence, either in vivo or in vitro.

Conclusion: This article can be used as a ready-to-use reference for therapeutic lead molecules from plants, marine and insect-derived natural products with PL inhibitory activity. The research is more focused on the discovery of more ingenious pancreatic lipase inhibitors with lesser consequences.

Keywords: Pancreatic lipase, obesity, natural lipase inhibitors, orlistat, polyphenols, alkaloids.

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Article Details

Year: 2021
Published on: 20 January, 2021
Page: [83 - 97]
Pages: 15
DOI: 10.2174/1573408017666210121114441
Price: $65

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PDF: 449