Nowadays, cancer is one of the deadliest diseases affecting an annually enormous number of people. Around 9.6
million people had died from different cancer types in 2018. Chemotherapy is considered to be a mainline treatment, and
systemic administration of a single anticancer agent is also considered as vital clinical debacles of chemotherapy in cancer
management. The formulators have been focusing currently onto procuring maximum benefit with the lowest aftereffects
and maximum safety and efficacy for the patients undergoing chemotherapy. This review offers a perspective on the future
developments of encapsulating food bioactive compounds with anticancer agents in a multifunctional single nanoliposomal
delivery system. In the last decade, the paradigm shift was seen in formulating drug delivery systems for cancer treatment.
Currently, food bioactive compounds are being taken as a hot subject by the researchers, especially for the treatment of
cancer owing to both preventative and curative quality. This review collects the utilization of liposomes in the delivery of
anticancer drugs by encapsulating with food bioactive compounds by the oral administration. The authors coined the name
of this combination is “Combisomes” as a fourth generation liposomes. Authors opine that “Combisomes” can tackle cancer
minimizing side effects encountered from the usual anticancer agents. “Combisomes” will purvey a safe platform for the
delivery of food bioactive compounds and anticancer agents for managing cancer with better safety prospects.
Keywords: Cancer, chemotherapy, liposomes, combisome, food bioactive compounds
Rights & PermissionsPrintExport