Dequalinium-derived Nanoconstructs: A Promising Vehicle for Mitochondrial Targeting

(E-pub Ahead of Print)

Author(s): Abhishek Pawar, Swati Korake, Kavita R. Gajbhiye*

Journal Name: Current Drug Delivery


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Abstract:

The power house of the cell; mitochondrion, is a vital organelle for drug targeting in the treatment of many diseases owing to its fundamental duties and function related to cell proliferation and death. The mitochondrial membrane comprises bilayer artifact and pose extremely negative potential which create hurdle for therapeutic molecules in reaching mitochondria. To accomplish mitochondrial targeting, the scientific community has explored diverse pharmaceutical formulations like liposomes, polymeric nanoparticles (NPs), and inorganic NPs. However, the game changing technology was modification of these carriers by mitochondriotropic moiety, dequalinium chloride (DQA) or delivering the chemotherapeutics by DQAsomes. The DQA represents a distinctive mitochondriotropic delocalized cation that display their selectivity towards accumulation in mitochondria of carcinoma cell. Attributed to this characteristics, DQAsomes have been formulated using DQA and explored for successful mitochondrial targeting of bioactives. In this review, we have discussed the effectiveness of DQA nanocarriers which efficiently and selectively transmit the cytotoxic drug to the tumor cell. The DQA based nanoformulations have evidently displayed augmented pharmacological and therapeutic outcome than their counterparts both in vitro and in vivo. Thus, DQAsomes symbolizes an ideal carrier with excellent potential as mitochondial targeting agent.

Keywords: Dequalinium chloride, DQAsomes, Mitochondrial targeting, Nanocarrier System, Vesicular nanosystem

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Article Details

(E-pub Ahead of Print)
DOI: 10.2174/1567201818999210120201252
Price: $95