Background: Dihydroquinazolinone derivatives are an important family of fused heterocyclic shows a wide
range of biological, medicinal and pharmacological properties such as anti-tumor, anti-biotic, diuretic, analgesic, antihypertonic,
anti-pyretic, anti-depressant, anti-histamine and vasodilation activities.
Introduction: So far some acid catalysts, e.g.; p-toluenesulfonic acid, silica sulfuric acid, zinc(II) perfluorooctanoate,
gallium(III) triflate, ionic liquid, Al(H2PO4)3, I2, montmorillonite K-10, Amberlyst-15, Al/Al2O3 and Fe3O4 nanoparticles,
have been reported to accomplish this three component reaction. Some of these methods have drawbacks such as toxic
solvents and catalysts, long reaction time, the use of expensive catalysts and adverse yields.
Method: A mixture of benzaldehydes (1mmol), isatoic anhydride (1 mmol), Glycine (1 mmol) and OImDSA (2 mL) were
stirred at room temperature for the required reaction times (1-2 h). The progress of the reaction was monitored by TLC
(EtOAc: petroleum ether 1:2). After completion of reaction, as indicated by TLC, the ionic liquid was separated by
extraction with 2×15 mL of water. The solid residue was separated by recrystallization from EtOH. The pure products were
collected in 86-97% yields.
Results: Herein, in order to achieve a more efficient synthesis method, to deplete side effects, reduce reaction steps,
increase efficiency and curtail reaction time, and also to continue our research on the synthesis of heterocyclic and
pharmaceutical compounds. We wish to report the mild synthesis of some derivatives of 2-aryl-quinazolin-4(1H)-ones from
isatoic anhydride and Glycine using OImDSA
Conclusion: In conclusion, we have developed a simple, green and efficient protocol for the synthesis of 2-aryl-quinazolin-
4(1H)-ones using OImDSA as an efficient and new procedure. Simplicity, easy practice, integrated with inexpensive,
environmentally friendly and reusable ionic liquid are notable attributes of this new method. To the best of our knowledge,
this is the first report for the synthesis of a new library of quinazolin-4(1H)-ones derived from Glycine as a natural substrate
based on green chemistry conditions.