Background: While significant strides have been made to avoid mortality during the treatment of chronic
diseases, it is still one of the biggest health-care challenges that have a profound effect on humanity. The development of
specific, sensitive, accurate, quick, low-cost, and easy-to-use diagnostic tools is therefore still in urgent demand.
Nanodiagnostics is defined as the application of nanotechnology to medical diagnostics that can offer many unique
opportunities for more successful and efficient diagnosis and treatment for infectious diseases.
Methods: In this review we provide an overview of infectious disease using nanodiagnostics platforms based on
nanoparticles, nanodevices for point-of-care (POC) applications.
Results: Current state-of-the-art and most promising nanodiagnostics POC technologies, including miniaturized
diagnostic tools, nanorobotics and drug delivery systems have been fully examined for the diagnosis of diseases. It also
addresses the drawbacks, problems and potential developments of nanodiagnostics in POC applications for chronic
Conclusions: While progress is gaining momentum in this field and many researchers have dedicated their time in
developing new smart nanodevices for POC applications for various chronic diseases, the ultimate aim of achieving longterm,
reliable and continuous patient monitoring has not yet been achieved. Moreover, the applicability of the
manufactured nanodevices to rural patients for on-site diagnosis, cost, and usability are the crucial aspects that require
more research, improvements, and potential testing stations. Therefore, more research is needed to develop the
demonstrated smart nanodevices and upgrade their applicability to hospitals away from the laboratories.