Implications of microRNAs in the Pathogenesis of Atherosclerosis and Prospects for Therapy

Author(s): Armita M. Gorabi, Mohsen Ghanbari, Thozhukat Sathyapalan, Tannaz Jamialahmadi, Amirhossein Sahebkar*

Journal Name: Current Drug Targets

Volume 22 , Issue 15 , 2021


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Abstract:

MicroRNAs (miRNAs) are non-coding RNAs containing around 22 nucleotides, which are expressed in vertebrates and plants. They act as posttranscriptional gene expression regulators, fine-tuning various biological processes in different cell types. There is emerging evidence on their role in different stages of atherosclerosis. In addition to regulating the inflammatory cells involved in atherosclerosis, miRNAs play fundamental roles in the pathophysiology of atherosclerosis, such as endothelial cell (EC) dysfunction, the aberrant function of the vascular smooth muscle cell (VSMC) and cholesterol metabolism. Moreover, miRNAs participate in several pathogenic pathways of atherosclerotic plaque development, including their effects on immune cell signaling receptors and lipid uptake. In this study, we review our current knowledge of the regulatory role of miRNAs in various pathogenic pathways underlying atherosclerosis development and also outline potential clinical applications of miRNAs in atherosclerosis.

Keywords: MicroRNA, Atherosclerosis, Inflammation, Clinical application, Immune cells, endothelial cell (EC).

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Article Details

VOLUME: 22
ISSUE: 15
Year: 2021
Published on: 20 January, 2021
Page: [1738 - 1749]
Pages: 12
DOI: 10.2174/1389450122666210120143450
Price: $65

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