The potential use of growth factors in stem cell-based therapies for the repair and regeneration
of tissues and organs offers a paradigm shift in regenerative medicine. Growth factors are
critical signalling molecules that play an important role in tissue development and remodelling.
Plasma rich in growth factor (PRGF) is a biotechnological strategy for the harvesting of the active
substances of platelets, including growth factors, from the patient’s blood. Because of their tremendous
essential growth factor and bioactive agents, as well as their paracrine mechanisms, PRGF
has been used as an efficacious option and adjuvant biological therapy in the repair and replacement
of damaged organs. This article provides an overview of PRGF extraction and its properties
and critically reviewed its clinical benefit and clinical trials in the treatment and regeneration of human
organs. Regenerative medicine is a multi-billion-dollar industry with huge interest to clinicians,
academics and industries, being considered as an emerging technology.
Keywords: Plasma rich in growth factor, regenerative medicine, ophthalmology, orthopaedic, dermatology, dentistry, stem
cells, human organs, tissue remodelling, cosmetic, growth factors, clinical, fat cells.
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