Electro-Acupuncture Protects Diabetic Nephropathy-Induced Inflammation Through Suppression of NLRP3 Inflammasome in Renal Macrophage Isolation

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Author(s): Jieying Zhang, Xiao Yang, Xinhuan Zhang, Dan Lu, Rui Guo*

Journal Name: Endocrine, Metabolic & Immune Disorders - Drug Targets
Formerly Current Drug Targets - Immune, Endocrine & Metabolic Disorders

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Background: With the increasing prevalence of diabetes in recent years, diabetic nephropathy (DN) has also become a dangerous disease that greatly endangers human health. The study was designed to determine the mechanism and effect of Electro-acupuncture (EA) in alleviating DN-induced inflammation.

Methods: Mice were intraperitoneally injected with STZ (streptozotocin, 50 mg/kg, S0130, Sigma, St. Louis, MO, USA) for five consecutive days. After 12 weeks after induction, blood glucose levels were measured (>300 mg/dL).

Results: The serum levels of IL-1β and IL-6 were decreased in EA-treated DN mice, and EA protected renal injury. EA could suppress HMGB1/NLRP3/NF-κB pathway. HMGB1 inhibition increased the anti-inflammatory effects of EA on DN by suppressing NLRP3/NF-κB pathway. The activation of HMGB1 attenuated the anti-inflammatory effects of EA on DN by inducing NLRP3/NF-κB pathway.

Conclusions: These results suggested that EA protected DN-induced inflammation through suppression of NLRP3 inflammasome.

Keywords: Electro-acupuncture, diabetic nephropathy, inflammasome, HMGB1

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(E-pub Ahead of Print)
DOI: 10.2174/1871530321666210118161721

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