HIV-1 integrase catalyzed the insertion of the viral DNA into the genome of human cells in the process of
retrotranscription. Integrase is an attractive target for HIV-1 treatment due to the lack of its homologue in human cells and
its vital role in HIV-1 replication. Although a major progress about the development of HIV-1 integrase inhibitors has been
made, some thorny problems, such as the drug resistance, led to the further study of HIV-1 integrase inhibitors. This review
briefly discussed the structure, function and mechanism of catalysis of HIV-1 integrase and made a further conclusion for
recent advances in small-molecule inhibitors of HIV-1 integrase.
Keywords: AIDS, Integrase, HIV-1 integrase inhibitors, Anti-AIDS drugs, Dual inhibitors, Allosteric integrase inhibitors
Rights & PermissionsPrintExport