Recent Advances in Small-Molecule HIV-1 Integrase Inhibitors

(E-pub Ahead of Print)

Author(s): Chao Zhang, Qian Xie, Chi Cheong Wan, Zhe Jin*, Chun Hu*

Journal Name: Current Medicinal Chemistry

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HIV-1 integrase catalyzed the insertion of the viral DNA into the genome of human cells in the process of retrotranscription. Integrase is an attractive target for HIV-1 treatment due to the lack of its homologue in human cells and its vital role in HIV-1 replication. Although a major progress about the development of HIV-1 integrase inhibitors has been made, some thorny problems, such as the drug resistance, led to the further study of HIV-1 integrase inhibitors. This review briefly discussed the structure, function and mechanism of catalysis of HIV-1 integrase and made a further conclusion for recent advances in small-molecule inhibitors of HIV-1 integrase.

Keywords: AIDS, Integrase, HIV-1 integrase inhibitors, Anti-AIDS drugs, Dual inhibitors, Allosteric integrase inhibitors

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(E-pub Ahead of Print)
DOI: 10.2174/0929867328666210114124744
Price: $95

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