Background: Coronavirus disease 2019 (COVID-19) outbreak has created an emergency
globally, and social distancing and isolation are the only solution to prevent its spread. Several
countries have announced a full lockdown to tackle this pandemic. The coronavirus family is inclusive
of pathogens of both- animal species and humans, encapsulating the isolated severe acute respiratory
syndrome coronavirus (SARS-CoV). Researchers around the globe have been dexterously
working to decode this lethal virus. Many mathematical frameworks have also been depicted,
which have helped to understand the dynamics of the COVID-19.
Methods: This systematic review highlights the virus genomic composition, preliminary phylogenetic
analysis, pathogenesis, symptomatology, diagnosis, and prognosis along with mathematical
models of disease transmission and dynamics.
Results: Our preliminary phylogenetic analysis of the novel coronavirus sequence discerns that although
shares its lineage with SARS, BAT-CoV, Beta-BAT-SARS, however, this protein is highly
dissimilar to its ancestors. The widely prominent amino acid residues found in the protein are alanine
(ALA), aspartic acid (ASP), phenylalanine (PHE), leucine (LEU), aspartic acid (ASP), threonine
(THR), valine (VAL), tyrosine (TYR) and asparagine (ASN) that are responsible for its replication
Conclusion: Research on coronaviruses continues towards developing a strong understanding of
the rapidly evolving viral replication and its transmission between individuals.