Recent Advances in the Application of Podophyllotoxin Derivatives to Fight Against Multidrug-Resistant Cancer Cells

Author(s): Qiuyan Guo, Enshe Jiang*

Journal Name: Current Topics in Medicinal Chemistry

Volume 21 , Issue 19 , 2021


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Abstract:

Podophyllotoxins, including epipodophyllotoxin derivatives, can act on a diverse array of drug targets in cancer cells and thus possess potent activity against various forms of cancer cell lines, including drug-resistant forms. Moreover, several podophyllotoxin derivatives represented by etoposide and teniposide, have already been approved for cancer therapy, demonstrating podophyllotoxin moiety as a useful pharmacophore for the discovery of novel anticancer agents. This review reports the recent advances in the exploitation of podophyllotoxin derivatives to fight against multidrug-resistant cancer cells. The mechanism of action and structure-activity relationship (SAR) studies are also highlighted.

Keywords: Podophyllotoxin, epipodophyllotoxin, anticancer, multidrug resistance, mechanism of action, structure-activity relationship.

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Article Details

VOLUME: 21
ISSUE: 19
Year: 2021
Published on: 13 January, 2021
Page: [1712 - 1724]
Pages: 13
DOI: 10.2174/1568026621666210113163327
Price: $95

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