Accelerator Production of Scandium Radioisotopes: Sc-43, Sc-44, and Sc-47

Author(s): Margarita Chernysheva, Shaun C. Loveless, Tom Brossard, Kaelyn Becker, Shelbie Cingoranelli, Eduardo Aluicio-Sarduy, Jeongseong Song, Paul Ellison, Jerry Nolen, David A. Rotsch, Suzanne E. Lapi, Jonathan W. Engle*

Journal Name: Current Radiopharmaceuticals

Volume 14 , Issue 4 , 2021


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Abstract:

Scandium radioisotopes are increasingly considered viable radiolabels for targeted molecular imaging (Sc-43, Sc-44) and therapy (Sc-47). Significant technological advances have increased the quantity and quality of available radioscandium in the past decade, motivated in part by the chemical similarity of scandium to therapeutic radionuclides like Lu-177. The production and radiochemical isolation techniques applied to scandium radioisotopes are reviewed, focusing on charged particle and electron linac initiated reactions and using calcium and titanium as starting materials.

Keywords: Scandium, cross-section, therapeutic radioisotopes, theranostics, PET, radioisotope production, radiochemical separation, radiometal, SPECT, radiolabeling.

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Article Details

VOLUME: 14
ISSUE: 4
Year: 2021
Page: [359 - 373]
Pages: 15
DOI: 10.2174/1874471014999210112205535
Price: $95

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