Scandium radioisotopes are increasingly considered viable radiolabels for targeted
molecular imaging (Sc-43, Sc-44) and therapy (Sc-47). Significant technological advances have increased
the quantity and quality of available radioscandium in the past decade, motivated in part by
the chemical similarity of scandium to therapeutic radionuclides like Lu-177. The production and
radiochemical isolation techniques applied to scandium radioisotopes are reviewed, focusing on
charged particle and electron linac initiated reactions and using calcium and titanium as starting materials.
Keywords: Scandium, cross-section, therapeutic radioisotopes, theranostics, PET, radioisotope production, radiochemical separation,
radiometal, SPECT, radiolabeling.
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