Aims: The study targeted to evaluate the antihyperglycemic activity of Salvia hispanica.
Background: Salvia hispanica L. (Lamiaceae) is a medicinal plant with many beneficial properties on human health.
Objective: This objective of the study was to investigate the antihyperglycemic effect of the aqueous extract of Salvia
hispanica (S. hispanica) seeds and its capacity to improve lipid profile in normal and STZ-induced diabetic rats.
Material and Methods: The seed aqueous extract of S. hispanica (SHSAE) at a dose of 100 mg/kg was administered
orally in normal and diabetic rats. The effect of oral SHSAE treatment on blood glucose and lipid levels during 15 days
was assessed in normal and streptozotocin-induced diabetic rats. The oral glucose tolerance test (OGTT) was carried out.
The antioxidant activity of SHSAE was also examined.
Results: The decrease of glycemia in rats following the administration of the plant extract suggested that the studied extract
possesses antidiabetic effect. The extract of S. hispanica produced hypolipidemic effect with a significant lowering effect on
plasma total cholesterol levels and increase on HDL-cholesterol levels. SHSAE was also able to enhance glucose tolerance
using OGTT. Moreover, SHSAE possess a potential antioxidant effect in vitro.
Conclusion: In conclusion, this study demonstrates the antihyperglycemic and antilipidemic effects of SHSAE in rats.