Polymers Based on Phenyl Boric Acid in Tumor-Targeted Therapy

(E-pub Ahead of Print)

Author(s): Dexia Luo, Zheng Yao*, Junzi Wu*

Journal Name: Anti-Cancer Agents in Medicinal Chemistry
(Formerly Current Medicinal Chemistry - Anti-Cancer Agents)


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Abstract:

Background: tumors are still one of the major challenges to human health. Tumor-targeted therapy is an effective way to treat tumors based on precise medical models. Sialic acid (SA) is overexpressed on the surface of tumor cells, and phenyl boric acid (PBA) can specifically bind to SA. However, studies on the use of PBA in tumor-targeted therapy are few.

Objective: To summarize and analyze the characteristics and influencing factors of tumor targeted therapy in recent years, and the influencing factors of phenyl boric acid modified polymers in tumor targeted therapy, such as hydrogen ion concentration (pH), adenosine triphosphate (ATP), and sugars .This paper describes the application of phenyl boric acid partially functionalized nanopolymers in various types of targeted tumors, such as breast cancer, lung adenocarcinoma, liver cancer, and so forth . In order to further improve the basic research and clinical workers' understanding of nano-preparations and tumor targeted therapy. At the same time, it is also hoped to promote the development value of phenyl boric acid.

Methods: The findings on tumor-targeted therapy and the role of partially functionalized polymers with PBA in different tumors at home and abroad were analyzed and summarized in recent years.

Results: Tumor-targeted therapy is a promising treatment for tumors. PBA promotes the treatment of tumors using SA, which is highly expressed on the surface of tumor cells.

Conclusions: Tumor-targeted therapy has shown great prospects for clinical application in recent years. PBA is beneficial as a member of the drug loading system. Further studies are still needed to promote its development and application.

Keywords: Phenyl boric acid, research progress, tumor-targeted therapy, sialic acid, ATP, nano-polymers

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Article Details

(E-pub Ahead of Print)
DOI: 10.2174/1871520621666210112122334
Price: $95

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