Breast cancer is the most common type of malignancy affecting women worldwide and also being the mostly diagnosed one. Mammography being the gold standard for diagnosis but there are high chances that it can give false- negative as well false-positive test results. Finding cost-effective, readily available and increased sensitivity as well as specificity for diagnosis is the need right now to decrease the mortality as well as morbidity rate. Application of biomarkers to the clinical use has paved way for a better prognosis, diagnosis, detection, screening and better clinical results. The efficacy of the treatment is enhanced. Biomarkers are known to cause advancement in breast cancer study and are expected to improve the quality of life in patients. Not only tissue biomarkers but serum and circulating biomarkers are also of significance in patients. This review highlights the particulars about the current use and application of biomarkers in effective prognosis, detection and treatment of breast cancer and also the ones which are currently being studied under trials and have the potential to be advantageous and more specific in the near future.