Ultrasonic Preparation and Reactivity of 4,5-dihydro-1H-pyrazole Derivatives

(E-pub Ahead of Print)

Author(s): Ahlem Guesmi, Naoufel Ben Hamadi*

Journal Name: Letters in Organic Chemistry


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Abstract:

The regiospecific synthesis of 1H-pyrazole derivatives has been accomplished through the 1,3-dipolar cycloaddition of aryldiazoalkane to but-3-en-2-one. A convenient and inexpensive ultrasound-assisted preparation of cyclopropenes in good yields has been realized. The effect of solvent, ultrasonic power, frequency, reaction time and temperature of cyclopropenation were studied and the order of yield indicates Ultrasound, 25 KHz > Ultrasound, 40 KHz > conventional synthesis method.

Keywords: 1, 3-Dipolar cycloaddition, ultrasound, frequency, Power, 4, 5-dihydro-1H-pyrazole, cyclopropenes

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Article Details

Published on: 07 January, 2021
(E-pub Ahead of Print)
DOI: 10.2174/1570178617666210108113916
Price: $95

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