Cubosomes are highly stable nanostructured liquid crystalline dosage delivery form, derived from
amphiphilic lipids and polymer-based stabilizers converting it in a form of effective biocompatible carrier for
the drug delivery. The delivery form comprised of bicontinuous lipid bilayers arranged in three-dimensional
honeycombs like structure provided with two internal aqueous channels for the incorporation of many s biologically
active ingredients. In contrast to liposomes, they provide a large surface area for the incorporation of different
types of ingredients. Due to the distinct advantages of biocompatibility and thermodynamic stability, cubosomes
have remained the first preference as a method of choice in the sustained release, controlled release,
and targeted release dosage forms as new drug delivery system for the better release of the drugs. As a lot of advancement
in the new form of dosage form brought the novel avenues in drug delivery mechanisms, so it was a
matter of worth to compile the latest updates on the various aspects of the mentioned therapeutic delivery system
including its structure, routes of applications along with the potential applications to encapsulate variety
drugs to serve health-related benefits.
Keywords: Cubosome, cubic phase, nanoparticles, bicontinuous, amphiphilic, drug delivery.
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