Among many reactive oxygen species (ROS), which are constantly generated during oxidative
stress in cellular membranes, the formation and subsequent reactivity of ubiquitous 4-hydroxy-2-
nonenal (HNE) with nearby amino acids and lipids represent one of the main research targets in cell
physiology in the last decades. Starting from the first synthesis of HNE in 1967, the chemistry and
reactivity of HNE are constantly under intense scrutiny. This review shows recent advances in the
field, which are discussed with the special emphasis on revealing intricate details of numerous reaction
mechanisms of HNE with lipids and amino acids, with the goal of understanding the reactivity of
HNE at the molecular level.
Keywords: 4-hydroxy-2-nonenal, oxidative stress, covalent modifications, model biological systems, reaction mechanism, lipid
modification, protein modification.
Rights & PermissionsPrintExport