Background: There is no single-component excipient that fulfills all the requisite performance
to allow an active pharmaceutical ingredient to be formulated into a specific dosage form.
Co-processing is a novel concept that incorporates a combination of two or more excipients, that is
advantageous and cannot be achieved using a physical admixture.
Objective: This review provides an overview of co-processed excipients, recent patents granted
and filed in this field and the commercial patented technology platforms based on these excipients.
Methods: Various online patent databases were used for collecting the information on recent patents
and patented co-processed excipient technologies. The recent patents such as single-step coprocessing
by dry coating, novel co-processed excipients for oily drugs and novel silica-coated
compositions have been discussed.
Results: Co-processed excipients are evolving as a current and future trend of excipient technology
in pharmaceutical manufacturing, which is evident by the increasing number of patents based on these
excipients. Among various techniques, the maximum number of patents is based on the spray
Conclusion: In this work, the authors have focussed on recent patents and commercial technologies
on co-processed excipient. A better understanding of this will help researchers and pharmaceutical
industries to select the appropriate platform, or to develop new innovative co-processed excipients
with improved tableting characteristics.