Gut microbiota (GM) as an organ of the human body has a particular and autonomous function that related to it.
This review aimed to investigate human intestinal and gut microbiota interaction and its impact on health. As a creation
referable database about this dynamic and complex organ, several comprehensive projects are implemented by using
culture-dependent (culturomics), culture independent methods (e.g metagenomics, mathematics model), and
Gnotobiological together. This study was done by searching PubMed, Scopus and Google scholar database in the gut, health
microbiota and interaction keywords. The first acquired microbiota during pregnancy or childbirth is colonized in the gut by
using specific and non-specific mechanisms. That`s structure and shape reach relative stability with selection pressure along
with host development until adulthood and keep its resilience against external or internal variables depending on the host
genetics and negative feedback. Due to several research individuals have 2 functional group microbiota including the core
(common between vast majorities human) and flexible (transient population) microbiome. The most important role of the
GM in the human body can be summarized in three basic landscapes: metabolic, immune system, and gut-brain axis
interaction. So that loss of microbial population balance will lead to disorder and disease.
Keywords: Gut microbiota, Composition, Metagenomic, Function, Interaction, Disease, Core microbiome, Dysbiosis
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