Increased level of interleukin-8 in female genital tract after HP eradication lines

(E-pub Abstract Ahead of Print)

Author(s): Viacheslav Kravtsov*, Tatiana Surovtceva, Maria Taame, Yuriy Grukhin, Natalia Kalinina

Journal Name: Infectious Disorders - Drug Targets
Formerly Current Drug Targets - Infectious Disorders

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The study investigated the levels of cytokines IL-8 and TNF-α in vaginal secretion in a group of female patients with Helicobacter-associated acid-related diseases who were or were not treated with antibiotics against anti-Helicobacter therapy. It turned out that the secretory cytokine (chemokine) IL-8 is dramatically increased in the vaginal mucosa in patients treated with antibiotics, specifically in post-menopause women. Thus, we conclude that helicobacter pylori eradication treatment affects the immune status of the female genital tract.

Keywords: Local immunity, female genital tract, interleukin-8 (IL-8), tumor necrosis factor-alpha (TNF-α), Helicobacter Pylori associated acid-related diseases, eradication lines.

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Article Details

(E-pub Abstract Ahead of Print)
DOI: 10.2174/1871526520666210104091545
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