Nanocarriers for Photodynamic Therapy Intended to Cutaneous Tumors

Author(s): Maria B.R. Pierre*

Journal Name: Current Drug Targets

Volume 22 , Issue 10 , 2021

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Graphical Abstract:


Photodynamic Therapy (PDT) is a therapeutic modality used for several malignant and premalignant skin disorders, including Bowen's disease skin cancers and Superficial Basal Cell Carcinoma (BCC). Several photosensitizers (PSs) have been explored for tumor destruction of skin cancers, after their activation by a light source of appropriate wavelength. Topical release of PSs avoids prolonged photosensitization reactions associated with systemic administration; however, its clinical usefulness is influenced by its poor tissue penetration and the stability of the active agent. Nanotechnology-based drug delivery systems are promising tool to enhance the efficiency for PDT of cancer. This review focuses on PSs encapsulated in nanocarriers explored for PDT of skin tumors.

Keywords: Photodynamic Therapy, skin cancers, nanotechnology, topical delivery, nanocarriers, photosensitizers.

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Article Details

Year: 2021
Published on: 01 January, 2021
Page: [1090 - 1107]
Pages: 18
DOI: 10.2174/1389450122999210101230743
Price: $65

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PDF: 47