Background: Malnutrition induced by dietary restriction produces several metabolic
changes that affect body weight, the digestive system, and annex organs, including the liver. Malnutrition
generates an inflammatory state and increases oxidative stress. The liver is one of the
body vital organs, becoming necessary to analyze the impact of food supplementation on the repair
of possible changes that may occur in this organ due to malnutrition.
Aims: To evaluate the effects of a low-cost supplementation derived from Buriti and dairy byproducts
on liver recovery in malnourished mice, focusing on the expression of oxidative stressrelated
genes, as well as biochemical and histological parameters.
Methods: Swiss mice were divided into six groups and submitted to two treatment phases: food restriction,
for malnutrition onset; and renutrition, with mice being fed with different diets.
Results: Our results indicate that dietary supplementation was successful in recovering liver damage
caused by malnutrition in animal models. The new supplement has been shown to recover liver
damage with similar or superior results compared to the commercial reference supplement on the
Conclusion: Our work presents a new composition of low cost food supplement based on buriti
and dairy by-products, proven to be effective in the malnutrition treatment of malnutrition. The improvements
were proven through the recovery of body weight, reduction of inflammation and oxidative