A Therapeutic Journey of 5-Pyrazolones as a Versatile Scaffold: A Review

Author(s): Ravinder Sharma, Pooja A. Chawla*, Viney Chawla, Rajeev Verma, Nandita Nawal, Vikas Gupta

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 21 , Issue 13 , 2021

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Graphical Abstract:


A sizeable proportion of currently marketed drugs come from heterocycles. The heterocyclic moiety 5-pyrazolone is well known five-membered ring containing nitrogen. Derivatives of this wonder nucleus have exhibited activities as diverse as antimicrobial, anti-inflammatory, analgesic, antidepressant, anticonvulsant, antidiabetic, antihyperlipidemic, antiviral, antitubercular, antioxidant, anticancer and antiviral, including action against severe acute respiratory syndrome (SARS) or 3C protease inhibitor. A number of drugs based on this motif have already made it to the market. Standard texts and literature on medicinal chemistry cite different approaches for the synthesis of 5- pyrazolones. The present review provides an insight view to 5-pyrazolone synthesis, their biological profile and structure-activity relationship studies.

Keywords: Pyrazolones, anti-inflammatory, anticancer, antidepressant, antidiabetic, coronavirus, structure activity relationship.

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Article Details

Year: 2021
Published on: 01 January, 2021
Page: [1770 - 1795]
Pages: 26
DOI: 10.2174/1389557521999210101224058
Price: $65

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