Biomimetic Copper Oxide Nanoparticles and its Validation Through In-silico Approach on Cardiac Enzymes

(E-pub Ahead of Print)

Author(s): Jacquline Rosy P, VenkatKumar Shanmugam*, Jebastin Sonia Jas, Santhoshkumar Jayakodi

Journal Name: Current Nanoscience


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Abstract:

Background: The present study outlines the green synthesis of copper oxide (GS-CuO) nanoparticles using Magnolia champaca plant floral extract for the first time. Computational analysis showed the role of GS-CuO nanoparticles on cardiac enzymes ACE2 and SOD1 functional expression through hydrogen bond interaction with amino acid residues.

Method: The synthesized GS-CuO nanoparticles were characterized by various techniques like X-Ray Diffraction, UVVis Spectrophotometer, Fourier Transform Infrared Spectroscopy, Scanning Electron Microscopy and Transmission Electron Microscopy.

Results: Nanoparticles demonstrate the presence of spherical shape and size 20 nm. The particles have many active sites and as compared to the bulk materials, and thus, the computational analysis was conducted against angiotensin-converting enzyme and superoxide dismutase to visualize the cardioprotective effects.

Conclusion: The in-silico approach established valuable information on cardioprotective effects of green synthesized oxide nanoparticles using Magnolia champaca.

Keywords: GS-CuO nanoparticles, magnolia champaca, GCMS, TEM, in-silico approach, LigPlot+

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(E-pub Ahead of Print)
DOI: 10.2174/1573413716666210101161139

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