Title:Exploring the Anti-Neuroinflammatory Potential of Steroid and Terpenoid-Derived Phytochemicals to Combat Alzheimer's Disease
VOLUME: 27
Author(s):Md. Tanvir Kabir, Md. Sahab Uddin*, Sonia Zaman, Md. Sohanur Rahman, Tapan Behl, Ausaf Ahmad, Abdul Hafeez, Asma Perveen and Ghulam Md Ashraf*
Affiliation:Department of Pharmacy, Brac University, Dhaka, Department of Pharmacy, Southeast University, Dhaka, Department of Pharmacy, Southeast University, Dhaka, Department of Biochemistry and Molecular Biology, University of Rajshahi, Rajshahi, Chitkara College of Pharmacy, Chitkara University, Punjab, Amity Institute of Biotechnology, Amity University Uttar Pradesh Lucknow Campus, Uttar Pradesh, Glocal School of Pharmacy, Glocal University, Saharanpur, Glocal School of Life Sciences, Glocal University, Saharanpur, King Fahd Medical Research Center, King Abdulaziz University, Jeddah
Abstract:Alzheimer's disease (AD) is an age-related progressive neurodegenerative disorder that significantly affects
cognitive functions in a way that causes loss of memory, thinking, and behavior. Multiple studies revealed that
neuroinflammation associated with AD is linked with the amyloid-beta deposition in the brain. Elevated levels of
expression of cytokines, microglial activation, nuclear factor kappa B, and reactive oxygen species play roles in ADrelated inflammatory processes. Indeed, effective therapeutic approaches are urgently required to develop therapeutic
agents to prevent and treat AD. So far, many anti-AD drug candidates have failed in the clinical stages and currently
available drugs only provide symptomatic treatment. In recent times, pharmacologically active phytochemicals have been
found to possess promising anti-neuroinflammatory effects; therefore these natural products can be useful in the AD
treatment. In this review, we have comprehensively discussed the role of neuroinflammation and the molecular processes
altered by multiple steroid and terpenoid-derived phytochemicals in various AD-related neuroinflammatory pathways.
Indeed, steroid and terpenoid-derived phytochemicals show important therapeutic activities, which can be useful in
ameliorating and treating AD-related neurodegeneration.
