Introduction: The most common treatment for Primary Open-Angle Glaucoma (POAG)
is the daily use of eye drops. Sustained-release drug delivery systems have been developed to improve
patient adherence by achieving prolonged therapeutic drug concentrations in ocular target tissues
while limiting systemic exposure. The purpose of this study is to compare the efficacy and
safety of bimatoprost inserts with bimatoprost eye drops in patients with POAG and Ocular Hypertension
Methods: We include OH and POAG patients aged between 40 and 75 years-old. Both OH and
POAG patients had intraocular pressure (IOP) greater than 21 and ≤30 mmHg at 9:00 am without
glaucoma medication and normal biomicroscopy. Five normal patients with IOP≤14 mmHg constitute
the control group. A chitosan-based insert of bimatoprost was placed at the upper conjunctival
fornix of the right eye. In the left eye, patients used one drop of LumiganTM daily at 10:00 pm.
For statistical analysis, a two-way analysis of variance (ANOVA), Student t-test, and paired t-test
Results: Sixteen POAG and 13 OH patients with a mean age of 61 years were assessed. In both
eyes, IOP reduction was similar during three weeks of follow-up (19.5±2.2 mmHg and 16.9±3.1
mmHg), insert, and eye drop, respectively; P=0.165). The percentage of IOP reduction in the third
week was 30% for insert and 35% for eye drops (P=0.165). No intolerance or discomfort with the
insert was reported. Among the research participants, 58% preferred the use of the insert while
25% preferred eye drops, and 17% reported no preference.
Conclusion: Bimatoprost-loaded inserts showed similar efficacy to daily bimatoprost eye drops
during three weeks of follow up, without major side effects. This might suggest a possible change
in the daily therapeutic regimen for the treatment of POAG and OH.